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Summary Table

Category	Details
Risk Factors	Elderly, young children, athletes, military recruits, outdoor laborers, obesity, dehydration, anticholinergic or diuretic use, lack of acclimatization, high ambient temperature with humidity
Etiology	Failure of thermoregulatory mechanisms leading to uncontrolled hyperthermia and multi-organ damage
Patient Presentation	Core temperature ≥40°C (104°F) with altered mental status (confusion, delirium, seizures, coma)
Classic Physical Exam	Hot skin (classically dry in non-exertional, may be diaphoretic in exertional), tachycardia, hypotension, tachypnea, neurological dysfunction
Key Diagnostic Results	Core temperature ≥40°C via rectal thermometer; elevated CK, transaminases, creatinine; coagulopathy (elevated PT/INR); metabolic acidosis with elevated lactate; possible rhabdomyolysis with myoglobinuria
Management	Immediate rapid cooling (evaporative cooling, ice water immersion); IV fluid resuscitation with isotonic crystalloids; airway protection; monitor for DIC, rhabdomyolysis, renal failure
Keywords	"Found unconscious after marathon," "elderly during heat wave," "hot dry skin," "confused after exertion," "temperature 41°C," "altered mental status in hot environment"

1. Pathophysiology

Heatstroke represents the most severe end of the heat illness spectrum. It occurs when the body's heat production or environmental heat absorption overwhelms its capacity to dissipate heat. Under normal conditions, the hypothalamus coordinates thermoregulation through cutaneous vasodilation and sweating. In heatstroke, this system fails catastrophically.

The core event is uncompensated hyperthermia, where the core body temperature rises above the critical thermal maximum (generally ≥40°C). At this temperature, direct cellular thermal injury begins. Proteins denature, cell membranes destabilize, and mitochondrial function collapses. This is why multi-organ damage occurs: it is not simply "being too hot" but rather a systemic inflammatory and cytotoxic cascade similar in character to sepsis.

The endothelial injury caused by heat triggers widespread activation of the coagulation cascade, which is why disseminated intravascular coagulation (DIC) is a feared complication. Simultaneously, the gut barrier becomes permeable ("gut translocation"), allowing endotoxins to enter the bloodstream and amplify the systemic inflammatory response. This creates a vicious cycle of inflammation, coagulopathy, and organ failure.

Skeletal muscle breakdown (rhabdomyolysis) is particularly prominent in exertional heatstroke. The combination of thermal injury and sustained muscle contraction causes myocyte necrosis, releasing myoglobin, CK, and potassium into the circulation. Myoglobin precipitates in renal tubules, leading to acute kidney injury (AKI). This directly explains the dark "cola-colored" urine and rising creatinine seen in these patients.

The central nervous system is exquisitely vulnerable to thermal injury. The cerebellum is especially sensitive, which is why ataxia may persist even after recovery. CNS dysfunction is the hallmark that separates heatstroke from lesser heat illnesses. If there is no altered mental status, it is not heatstroke by definition.

2. Classification and Clinical Manifestation

Feature	Classic (Non-Exertional) Heatstroke	Exertional Heatstroke
Population	Elderly, chronically ill, sedentary individuals	Young, healthy athletes, military recruits, laborers
Setting	Prolonged heat wave exposure, poorly ventilated housing	Strenuous physical activity in hot/humid conditions
Onset	Gradual (hours to days)	Rapid (minutes to hours)
Skin	Hot and dry (sweating mechanism has failed)	Hot and may still be diaphoretic (sweating can persist)
Rhabdomyolysis	Less common	Very common and often severe
Lactic acidosis	Mild to moderate	Often severe
DIC	Present in severe cases	More frequent and earlier onset
Acute Kidney Injury	Prerenal (dehydration-driven) predominates	Intrinsic renal injury from myoglobin is common
Hypoglycemia	Less common	May occur due to glycogen depletion
Core Temperature	≥40°C (104°F)	≥40°C (104°F), can exceed 42°C
CNS Dysfunction	Confusion, delirium, coma	Confusion, combativeness, seizures, coma

The classic teaching that heatstroke presents with "hot, dry skin" applies most reliably to the non-exertional form. In exertional heatstroke, the patient may still be sweating profusely. Do not rule out heatstroke simply because the skin is moist. The defining criterion is always elevated core temperature plus CNS dysfunction.

3. Diagnostic Workup

Test	Purpose	Expected Findings
Rectal temperature (Best Initial Test)	Confirm core hyperthermia	≥40°C (104°F); oral/axillary readings are unreliable and underestimate true core temperature
CBC	Evaluate for hemoconcentration, infection	Leukocytosis (stress response); thrombocytopenia if DIC developing
BMP/CMP	Assess renal function, electrolytes	Elevated BUN/creatinine (AKI); hyperkalemia (from rhabdomyolysis); hypocalcemia; hyperphosphatemia
Creatine kinase (CK)	Screen for rhabdomyolysis	Markedly elevated (often >10,000 U/L in exertional); rising CK over 24 hours is a red flag
Coagulation studies (PT, PTT, fibrinogen, D-dimer)	Evaluate for DIC	Prolonged PT/PTT, low fibrinogen, elevated D-dimer
Hepatic panel (AST, ALT)	Assess liver injury	Transaminases often markedly elevated; hepatic failure is a major cause of delayed death
Arterial blood gas (ABG)	Assess acid-base status	Metabolic acidosis with elevated lactate; respiratory alkalosis may coexist early due to tachypnea
Urinalysis	Screen for myoglobinuria	Dark, tea- or cola-colored urine; dipstick positive for "blood" without RBCs on microscopy (myoglobin cross-reacts)
Serum lactate	Gauge tissue hypoperfusion severity	Elevated; correlates with prognosis
CT head	Rule out intracranial pathology if altered mental status persists	Typically normal acutely; obtained to exclude stroke, hemorrhage as alternative diagnoses

The best initial diagnostic step is measuring core body temperature with a rectal thermometer. This point is heavily tested. Oral, tympanic, and axillary thermometers are not acceptable substitutes because they systematically underestimate core temperature, especially in patients who are tachypneic or have been given oral fluids.

Once core temperature confirms hyperthermia (≥40°C) and the clinical picture includes altered mental status, the diagnosis of heatstroke is established clinically. There is no single confirmatory laboratory test that "makes" the diagnosis. Instead, laboratory workup serves to assess the severity of end-organ damage and guide management.

The most important labs to order immediately are CK (to quantify rhabdomyolysis), coagulation panel (to screen for DIC), hepatic transaminases (liver injury is a hallmark of severe heatstroke and a predictor of mortality), and a basic metabolic panel (to identify hyperkalemia, which can be life-threatening, and to monitor renal function).

An ABG with lactate helps stratify severity. A urinalysis showing dipstick-positive heme without red blood cells on microscopy is the classic finding of myoglobinuria and should immediately raise concern for impending renal failure.

Serial lab monitoring over the first 24 to 48 hours is essential because hepatic injury and DIC often peak 24 to 72 hours after the initial insult, even after temperature has normalized.

4. Management and Treatment

Phase	Intervention	Details
Immediate (Field/ED)	Rapid cooling	Goal: reduce core temp to <39°C within 30 minutes. Cold water immersion (best method for exertional); evaporative cooling with misting fans (preferred for classic/elderly); apply ice packs to neck, axillae, groin. Stop cooling at 38 to 38.5°C to avoid overshoot hypothermia.
Immediate	Airway management	Intubate if GCS ≤8 or unable to protect airway
Immediate	IV fluid resuscitation	Normal saline or lactated Ringer's; bolus 1 to 2 L initially, then titrate to urine output ≥1 to 2 mL/kg/hr (higher target if rhabdomyolysis present)
Supportive	Benzodiazepines	For seizures or shivering (shivering generates heat and counteracts cooling); lorazepam 1 to 2 mg IV or diazepam 5 to 10 mg IV
Supportive	Rhabdomyolysis protocol	Aggressive IV crystalloid resuscitation targeting urine output of 200 to 300 mL/hr; consider IV sodium bicarbonate to alkalinize urine (goal urine pH >6.5) to reduce myoglobin precipitation
Monitoring	Serial labs	Repeat CK, hepatic panel, coagulation studies, renal function every 6 to 12 hours for 48 to 72 hours
Monitoring	ICU admission	All heatstroke patients require ICU-level monitoring
NOT indicated	Antipyretics (acetaminophen, NSAIDs)	Antipyretics do not work in heatstroke. The hyperthermia is not mediated by prostaglandins or a reset hypothalamic set point. Acetaminophen may worsen hepatic injury. NSAIDs may worsen renal injury.
NOT indicated	Dantrolene	Not routinely recommended; heatstroke is not malignant hyperthermia, despite superficial similarity

The single most important intervention and the "next best step" on any exam question involving heatstroke is immediate aggressive cooling. Every minute of delay in cooling increases mortality and the risk of permanent neurological injury. This is the core competency being tested: recognizing that cooling takes priority over everything except basic airway management.

Cold water immersion (immersing the patient in an ice water bath at approximately 1 to 2°C) is the most effective cooling method and is the gold standard for exertional heatstroke. It achieves cooling rates of approximately 0.15 to 0.35°C per minute. In the classic/elderly form, where immersion may be impractical or risky (cardiac comorbidities, frailty), evaporative cooling is preferred: undress the patient, spray with lukewarm water, and direct high-flow fans over the body. This exploits the latent heat of evaporation.

Ice packs placed over areas with large superficial blood vessels (neck, axillae, groin) are a useful adjunct but should not be relied on as the sole method.

Cooling should be discontinued once core temperature reaches 38 to 38.5°C to prevent iatrogenic hypothermia, as the thermoregulatory system continues to be impaired and temperature can overshoot downward.

Shivering is a critical problem during cooling because it generates heat and opposes the cooling effort. If the patient shivers, administer benzodiazepines (lorazepam 1 to 2 mg IV) to suppress it. This is a frequently tested concept.

For patients with rhabdomyolysis (CK >5,000 U/L or rising), the fluid resuscitation target is higher: aim for urine output of 200 to 300 mL/hr to flush myoglobin through the renal tubules and prevent acute tubular necrosis. Urine alkalinization with sodium bicarbonate is sometimes used to increase myoglobin solubility, though evidence is not definitive.

A commonly tested contraindication: do not give antipyretics. This is a high-yield trap. Acetaminophen and NSAIDs target the prostaglandin-mediated fever pathway (where the hypothalamic set point is elevated by pyrogens). In heatstroke, the set point is normal but the body simply cannot dissipate heat. Antipyretics will not lower temperature and may cause harm: acetaminophen worsens hepatotoxicity, and NSAIDs impair renal function and platelet aggregation.

5. Differential Diagnosis and Distractors

Differential	Why It Looks Similar	Key Discriminator
Heat Exhaustion	Also occurs in hot environments; patient may have nausea, weakness, tachycardia, diaphoresis	No altered mental status and temperature is <40°C. The moment the vignette describes confusion, seizures, or loss of consciousness with temp ≥40°C, it is heatstroke, not heat exhaustion.
Neuroleptic Malignant Syndrome (NMS)	Hyperthermia, altered mental status, muscle rigidity, autonomic instability	History of antipsychotic medication use (typically started or dose-increased recently); characterized by "lead-pipe" rigidity; onset over days, not hours in a hot environment. Elevated CK is present in both.
Malignant Hyperthermia	Extreme hyperthermia, muscle rigidity, rhabdomyolysis, metabolic acidosis	Occurs exclusively during or shortly after general anesthesia with volatile anesthetic agents or succinylcholine. Treated with dantrolene (unlike heatstroke).
Serotonin Syndrome	Hyperthermia, altered mental status, autonomic dysfunction	Clonus, hyperreflexia, and myoclonus are prominent (not typical of heatstroke); history of serotonergic drug use (SSRIs, MAOIs, tramadol); onset within 24 hours of drug initiation or dose change.
Thyroid Storm	Hyperthermia, tachycardia, altered mental status, diaphoresis	History of hyperthyroidism or Graves disease; presence of goiter, exophthalmos, or lid lag; triggered by surgery, infection, or iodine load, not environmental heat.
Meningitis/Encephalitis	Fever with altered mental status	Nuchal rigidity, photophobia, headache are prominent; CSF analysis is diagnostic; no environmental heat exposure context.
Anticholinergic Toxicity	Hyperthermia, altered mental status, hot dry skin, tachycardia	"Mad as a hatter, blind as a bat, dry as a bone, red as a beet, hot as a hare." Mydriasis (dilated pupils), urinary retention, absent bowel sounds, and dry mucous membranes distinguish this. History of medication or plant ingestion.

6. Traps and High-Yield Pearls

The single most common trap on heatstroke questions involves antipyretics. Students who see a febrile, altered patient instinctively reach for acetaminophen or ibuprofen. The exam tests whether you understand that heatstroke hyperthermia is mechanistically different from infectious fever. The hypothalamic set point is not elevated. Prostaglandin inhibition will not help. The correct answer is always physical cooling methods.

A second frequent trap involves the skin finding. Many students are taught "heatstroke equals hot and dry skin" and will rule out heatstroke when the vignette describes a diaphoretic patient. This is wrong for exertional heatstroke, where sweating may still be intact. The defining feature is core temperature ≥40°C plus CNS dysfunction, not the presence or absence of sweat.

A third testing pattern involves the distinction between heat exhaustion and heatstroke. The vignette will describe a patient in a hot environment with nonspecific symptoms (nausea, fatigue, cramps, heavy sweating). The discriminator is always mental status. If the patient is alert and oriented, it is heat exhaustion. If there is any confusion, combativeness, delirium, seizure, or loss of consciousness, it is heatstroke, and the management shifts from simple oral rehydration and rest to aggressive cooling, IV fluids, and ICU monitoring.

Finally, be aware of the delayed complication trap. A question may present a patient who was cooled successfully and whose temperature normalized, then deteriorates 48 to 72 hours later with coagulopathy, jaundice, or oliguria. The answer is usually hepatic failure or DIC, which can manifest with delayed onset. Serial monitoring is not optional; it is standard of care.

The core competency tested across all heatstroke questions is your ability to recognize the emergency, prioritize rapid cooling above all pharmacologic interventions, avoid the antipyretic trap, and anticipate multiorgan failure as a downstream consequence.

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