2d:I[856015,["/_next/static/immutable/chunks/1xzisbplk9czp.js","/_next/static/immutable/chunks/3j2i1faptc_-9.js","/_next/static/immutable/chunks/0fma7nlq6immz.js","/_next/static/immutable/chunks/08tq8rmv423j5.js","/_next/static/immutable/chunks/1chr5wkk3j58k.js","/_next/static/immutable/chunks/37kmmh_zm4dov.js","/_next/static/immutable/chunks/311zvdjfxff-f.js","/_next/static/immutable/chunks/1a_hqhrsle_n_.js"],"default"] 2e:T5111,

Summary Table

Domain	Detail
Risk Factors	Males aged 15 to 25; tall/thin body habitus; left-sided predominance (~85 to 90%); puberty onset
Etiology	Dilation of the pampiniform venous plexus due to incompetent venous valves; left testicular vein drains into the left renal vein at a perpendicular angle, creating higher hydrostatic pressure
Patient Presentation	Dull, aching scrotal pain or heaviness that worsens with prolonged standing or physical exertion and improves with recumbency; may present with infertility workup
Classic Physical Exam	"Bag of worms" palpable above the testis; enlarges with Valsalva maneuver; decompresses when supine; ipsilateral testicular atrophy in advanced cases
Key Diagnostic Results	Color Doppler ultrasound showing dilated veins of the pampiniform plexus (>3 mm) with retrograde venous flow on Valsalva; semen analysis showing oligospermia or asthenospermia
Management	Observation if asymptomatic and fertility is not a concern; surgical varicocelectomy (microsurgical subinguinal approach preferred) or percutaneous embolization for symptomatic cases, infertility, or testicular atrophy
Keywords	"Bag of worms," left-sided scrotal swelling, infertility, worsens with standing/Valsalva, improves supine, testicular atrophy, pampiniform plexus

1. Pathophysiology

The pampiniform venous plexus is a network of veins that drains the testis, running within the spermatic cord. This plexus serves a thermoregulatory function by acting as a countercurrent heat exchanger, cooling arterial blood before it reaches the testis. Normal spermatogenesis requires a testicular temperature approximately 2 to 3 degrees Celsius below core body temperature. When the valves within these veins become incompetent, blood pools and the veins dilate, producing a varicocele.

The overwhelming left-sided predominance is explained by anatomy. The left testicular (gonadal) vein drains into the left renal vein at a near-perpendicular angle, which creates a column of hydrostatic pressure that the valves must resist. In contrast, the right testicular vein drains directly into the inferior vena cava (IVC) at an oblique angle, which is hemodynamically more favorable. Additionally, the left testicular vein is longer, and the left renal vein may be compressed between the superior mesenteric artery and the aorta (the nutcracker phenomenon), further increasing venous pressure.

The link between varicocele and infertility is the single most tested connection. Venous stasis raises intrascrotal temperature, disrupting spermatogenesis. The elevated temperature leads to increased oxidative stress, impaired Leydig cell function, and accumulation of gonadotoxic metabolites. This produces oligospermia (low sperm count), asthenospermia (poor motility), and abnormal sperm morphology. Varicocele is considered the most common correctable cause of male infertility, present in approximately 15% of the general male population but found in up to 35 to 40% of men presenting with primary infertility.

Testicular atrophy occurs when prolonged venous congestion and elevated temperature cause progressive damage to the seminiferous tubules. In adolescents, this is tracked by comparing testicular volume using an orchidometer; a volume differential greater than 2 mL between the affected and unaffected testis is considered significant.

2. Classification and Clinical Manifestation

Clinical Grading System

Grade	Examination Finding	Clinical Significance
Subclinical	Not palpable, not visible; detected only on imaging (Doppler ultrasound)	Generally does not require treatment; incidental finding
Grade I	Palpable only during Valsalva maneuver; not visible	May warrant monitoring, especially in adolescents
Grade II	Palpable at rest without Valsalva; not visible	Often symptomatic; commonly associated with semen parameter changes
Grade III	Visible through scrotal skin and easily palpable ("bag of worms")	Strongly associated with testicular atrophy and impaired spermatogenesis

Clinical Manifestation Spectrum

Presentation	Details
Asymptomatic	Discovered incidentally on physical exam or during infertility evaluation; the most common presentation
Scrotal discomfort	Dull, dragging ache or heaviness in the scrotum; characteristically worsens with standing, exercise, or at the end of the day; improves with lying down
Infertility	Abnormal semen analysis (oligospermia, asthenospermia, teratospermia); varicocele found during workup for couples unable to conceive
Testicular atrophy	Decreased ipsilateral testicular volume; particularly important in adolescent patients where growth arrest may be the only indication for intervention
Acute presentation	Rare; sudden onset of scrotal pain may mimic torsion or epididymitis and requires urgent evaluation

3. Diagnostic Workup

Test	Role	Key Findings
Physical examination	Best initial test	"Bag of worms," Valsalva augmentation, decompression when supine
Scrotal color Doppler ultrasound	Confirmatory / most accurate test	Pampiniform plexus vein diameter >3 mm; retrograde venous flow during Valsalva
Semen analysis	Functional assessment	Oligospermia, asthenospermia, increased abnormal morphology
Serum hormones (FSH, LH, testosterone)	Supplementary in infertility workup	Elevated FSH may suggest seminiferous tubule damage; low testosterone may indicate Leydig cell dysfunction
CT abdomen/pelvis	Not routine; indicated for red-flag presentations	Rule out retroperitoneal mass or renal tumor when a new right-sided or non-decompressing varicocele appears in an older patient

The best initial test is a thorough physical examination performed with the patient standing. The examiner palpates the spermatic cord above the testis. A varicocele feels like a cluster of dilated, tortuous veins, classically described as a "bag of worms." The patient is then asked to perform a Valsalva maneuver (bearing down), which increases intra-abdominal pressure, prevents venous return, and causes the varicocele to distend further. The examination is repeated in the supine position; a true varicocele should decompress when the patient lies down because gravity-assisted drainage is restored.

The most accurate test is scrotal color Doppler ultrasonography. This confirms the diagnosis by demonstrating dilated veins of the pampiniform plexus with a diameter exceeding 3 mm. The hallmark finding is reversal of venous flow (retrograde flow) during Valsalva. Doppler is also critical for measuring testicular volume, identifying concurrent pathology such as hydrocele or epididymal cysts, and evaluating subclinical varicoceles that are not palpable on exam.

A semen analysis should be obtained in any adult male presenting with infertility concerns. The classic pattern is a "stress pattern" showing decreased count, decreased motility, and increased abnormal forms. This test is not diagnostic of varicocele itself but is essential for determining functional impact and guiding treatment decisions.

A critical red-flag scenario on an exam: an older male (over 40) presenting with a new-onset, isolated right-sided varicocele, or a left-sided varicocele that does not decompress when supine, warrants CT imaging of the abdomen and pelvis. This presentation raises suspicion for a retroperitoneal mass, most commonly renal cell carcinoma invading or compressing the gonadal vein or IVC. This is one of the highest-yield associations tested.

4. Management and Treatment

Clinical Scenario	Management	Details
Asymptomatic, no fertility concerns, normal testicular size	Observation and annual follow-up	No intervention needed; reassess if symptoms develop or fertility is desired
Symptomatic (pain)	Conservative trial first, then surgical repair	Scrotal support, NSAIDs; proceed to repair if conservative measures fail
Infertility with abnormal semen analysis	Surgical varicocelectomy (preferred) or percutaneous embolization	Microsurgical subinguinal approach has the lowest recurrence and complication rates
Adolescent with testicular atrophy (>2 mL volume differential or >20% size discrepancy)	Surgical varicocelectomy	Prevents further growth arrest; catch-up growth often observed postoperatively
Non-decompressing or isolated right-sided varicocele	CT abdomen/pelvis first	Rule out retroperitoneal or renal malignancy before any varicocele-directed therapy

Conservative management is the first-line approach for patients with mild symptoms and no fertility concerns. This includes wearing supportive underwear, avoiding prolonged standing, and using nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen 400 to 600 mg every 6 to 8 hours as needed for pain.

Surgical varicocelectomy is the treatment of choice when intervention is indicated. The microsurgical subinguinal (Marmar) approach is preferred because it allows direct visualization and preservation of the testicular artery and lymphatic channels under operative magnification. This technique carries the lowest recurrence rate (approximately 1 to 2%) and the lowest risk of hydrocele formation compared to other approaches. Alternative surgical approaches include the inguinal (Ivanissevich) and retroperitoneal (Palomo) techniques, though these carry higher recurrence and complication rates. Laparoscopic varicocelectomy is another option but offers no clear advantage over the microsurgical approach.

Percutaneous venous embolization is a minimally invasive alternative performed by interventional radiology. A catheter is advanced into the gonadal vein, and embolic agents (coils or sclerosant) are deployed to occlude the refluxing vein. This approach avoids general anesthesia and has a shorter recovery time, making it suitable for patients who are poor surgical candidates. However, the recurrence rate is somewhat higher (approximately 4 to 11%) compared to microsurgical repair.

Indications for surgical repair (the testable list):

Palpable varicocele with documented infertility and abnormal semen parameters
Symptomatic varicocele refractory to conservative management
Adolescent with ipsilateral testicular growth arrest (volume differential >2 mL or >20% size discrepancy)
Hypogonadal symptoms with low serum testosterone in the setting of a varicocele

Postoperative outcomes: semen parameters improve in approximately 60 to 80% of men following repair, and spontaneous pregnancy rates increase to approximately 30 to 50%. Improvement in semen analysis is typically seen within 3 to 6 months after surgery, as spermatogenesis takes roughly 74 days per cycle.

5. Differential Diagnosis and Distractors

Differential	Why It Is Similar	Key Discriminator
Inguinal hernia	Scrotal/inguinal swelling that may increase with Valsalva	Hernia produces a smooth, reducible bulge with a palpable impulse at the external ring; bowel sounds may be auscultated; varicocele feels like a distinct "bag of worms" limited to the spermatic cord
Hydrocele	Painless scrotal swelling	Hydrocele transilluminates (light passes through fluid); it is a smooth, non-tender swelling that surrounds the testis; varicocele does not transilluminate and is located above/posterior to the testis
Epididymitis	Scrotal pain, may be left-sided	Epididymitis presents with acute onset, fever, dysuria, and a tender, swollen epididymis; pain improves with scrotal elevation (positive Prehn sign); varicocele pain is chronic, dull, and positional
Testicular torsion	Acute scrotal pain in a young male	Torsion is sudden, severe, with nausea/vomiting; absent cremasteric reflex; high-riding, transversely oriented testis; absent blood flow on Doppler; this is a surgical emergency unlike varicocele
Spermatocele	Painless cystic scrotal mass	Spermatocele is a well-circumscribed, transilluminating cyst located at the head of the epididymis, separate from the testis; it does not change with Valsalva or position
Testicular tumor	Painless scrotal mass in a young male	Tumor presents as a firm, non-tender, non-transilluminating mass within the testis itself; does not change with Valsalva; ultrasound shows a solid intratesticular lesion

6. Traps and High-Yield Pearls

The single most common trap with varicocele questions involves the non-decompressing varicocele or isolated right-sided varicocele in an older patient. Students who reflexively choose "scrotal ultrasound" or "varicocelectomy" without considering a retroperitoneal cause will get this wrong. When a vignette describes a varicocele that fails to reduce in the supine position, or a new varicocele appearing in a man over 40, or an isolated right-sided varicocele, the next best step is cross-sectional imaging (CT abdomen/pelvis) to evaluate for renal cell carcinoma or a retroperitoneal mass compressing the gonadal vein or IVC. This is the classic "don't miss" diagnosis hidden inside a varicocele question.

A second common error involves confusing the indication for treatment. Not every varicocele needs repair. Students must recognize that asymptomatic varicoceles with normal semen parameters and normal testicular size are managed with observation alone. The decision to intervene hinges on three pillars: symptoms refractory to conservative measures, documented infertility with abnormal semen analysis, or testicular growth arrest in adolescents.

A third tested concept is the mechanism linking varicocele to infertility. When a question asks "why" this patient is infertile, the answer centers on elevated intrascrotal temperature disrupting spermatogenesis, not on obstruction or hormonal deficiency. The question is testing whether you understand the thermoregulatory role of the pampiniform plexus.

Finally, remember the classic physical exam sequence: examine standing, confirm with Valsalva, then reexamine supine. If this sequence is described in the stem and the mass behaves as expected (enlarges with Valsalva, decompresses supine), the diagnosis is varicocele. If the mass does not decompress, shift your thinking to an obstructive etiology and order abdominal imaging. The core competency being tested is your ability to distinguish a benign anatomical variant from a red-flag presentation requiring urgent evaluation.

1e:["$","$L2d",null,{"article":{"id":"bc4e3944-5d75-4546-8349-b3982d416610","title":"Varikokel","content":"$2e","category":"Uronefrologi","created_at":"2026-08-21T05:03:58.886435+00:00","status":"published","subcategory":null},"questionCount":0,"sections":[{"id":"section-pathophysiology","num":"01","title":"Pathophysiology"},{"id":"section-classification-and-clinical-manifestation","num":"02","title":"Classification and Clinical Manifestation"},{"id":"section-diagnostic-workup","num":"03","title":"Diagnostic Workup"},{"id":"section-management-and-treatment","num":"04","title":"Management and Treatment"},{"id":"section-differential-diagnosis-and-distractors","num":"05","title":"Differential Diagnosis and Distractors"},{"id":"section-traps-and-high-yield-pearls","num":"06","title":"Traps and High-Yield Pearls"}],"hasSummaryTable":true}]