2d:I[856015,["/_next/static/immutable/chunks/1xzisbplk9czp.js","/_next/static/immutable/chunks/3j2i1faptc_-9.js","/_next/static/immutable/chunks/0fma7nlq6immz.js","/_next/static/immutable/chunks/08tq8rmv423j5.js","/_next/static/immutable/chunks/1chr5wkk3j58k.js","/_next/static/immutable/chunks/37kmmh_zm4dov.js","/_next/static/immutable/chunks/311zvdjfxff-f.js","/_next/static/immutable/chunks/1a_hqhrsle_n_.js"],"default"] 2e:T5a50,

Summary Table

Category	Details
Risk Factors	Children aged 2-7 years (ethmoid sinuses are the first to develop and pneumatize), recent upper respiratory tract infection (URI), daycare attendance, allergic rhinitis, immunocompromised states, cystic fibrosis, ciliary dyskinesia
Etiology	Bacterial: Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis; in complicated cases, Staphylococcus aureus (including MRSA) and polymicrobial anaerobes
Patient Presentation	Medial canthal or periorbital pain, nasal congestion with purulent rhinorrhea persisting beyond 10 days or biphasic worsening ("double sickening"), fever, headache localized between or behind the eyes
Classic Physical Exam	Periorbital edema (particularly medial canthal swelling), tenderness over the medial orbit/nasal bridge, erythema and warmth of the overlying skin, purulent drainage from the middle meatus on anterior rhinoscopy, proptosis and restricted extraocular movements if orbital extension has occurred
Key Diagnostic Results	CT sinuses with contrast: opacification of ethmoid air cells, mucosal thickening; in complicated cases, subperiosteal abscess, orbital fat stranding, or intracranial extension; elevated WBC with left shift and elevated CRP/ESR
Management	Uncomplicated: amoxicillin-clavulanate as first-line; complicated (orbital/intracranial involvement): IV ampicillin-sulbactam or clindamycin + ceftriaxone, urgent ophthalmology and ENT consultation, surgical drainage if abscess is present
Keywords	"Medial canthal swelling," "periorbital cellulitis in a child," "double sickening," "purulent rhinorrhea > 10 days," "ethmoid opacification on CT," "subperiosteal abscess"

1. Pathophysiology

The ethmoid sinuses hold a unique position in both anatomy and clinical testing because they are the first paranasal sinuses to pneumatize at birth, making them the most clinically relevant sinuses in young children. They consist of a honeycomb-like labyrinth of thin-walled air cells located between the orbits, separated from the orbital contents by the lamina papyracea, a paper-thin bony plate.

Ethmoiditis begins when mucosal inflammation, most commonly triggered by a preceding viral URI, causes obstruction of the ostiomeatal complex. This obstruction impairs mucociliary clearance and creates a stagnant, oxygen-poor environment within the ethmoid air cells. Secondary bacterial colonization then occurs, leading to purulent infection. The inflammatory cascade produces mucosal edema, accumulation of purulent secretions, and increased intrasinusal pressure.

The reason ethmoiditis is heavily tested is its anatomical proximity to the orbit. The lamina papyracea is not only extremely thin but also contains natural bony dehiscences and traversing neurovascular foramina. These serve as direct routes for infection to spread from the ethmoid sinus into the orbital periosteum and orbital fat. This is why a child presenting with simple "sinusitis" can rapidly deteriorate into preseptal cellulitis, postseptal (orbital) cellulitis, subperiosteal abscess, orbital abscess, or even cavernous sinus thrombosis. The venous drainage of the ethmoid sinuses communicates with the valveless ophthalmic veins, which drain directly into the cavernous sinus, creating a pathway for retrograde septic thrombophlebitis without the protection of venous valves.

Additionally, the superior boundary of the ethmoid sinus is the cribriform plate of the anterior cranial fossa. Erosion through this boundary can lead to intracranial complications including epidural abscess, subdural empyema, and meningitis.

Understanding this anatomy explains why the clinical presentation progresses in a predictable pattern: nasal congestion and purulent drainage (mucosal obstruction) followed by medial canthal edema (periosteal inflammation near the lamina papyracea) followed by proptosis and ophthalmoplegia (true orbital invasion).

2. Classification and Clinical Manifestation

Ethmoiditis is best understood through the Chandler Classification of orbital complications, as this is the framework most commonly tested. The disease exists on a spectrum from uncomplicated sinusitis to life-threatening intracranial extension.

Stage	Classification	Clinical Manifestation
I	Preseptal (Periorbital) Cellulitis	Eyelid edema, erythema, and warmth anterior to the orbital septum; no proptosis, no pain with eye movement, full extraocular motility, normal visual acuity
II	Orbital Cellulitis	Diffuse orbital fat inflammation posterior to the septum; proptosis, chemosis, restricted and painful extraocular movements, possible decreased visual acuity
III	Subperiosteal Abscess	Collection of pus between the periosteum and the lamina papyracea; proptosis with globe displacement (typically laterally and inferiorly), restricted motility, may have fluctuant medial canthal mass
IV	Orbital Abscess	Discrete abscess within the orbital fat; severe proptosis, complete ophthalmoplegia, markedly decreased vision, afferent pupillary defect
V	Cavernous Sinus Thrombosis	Bilateral orbital signs (begins unilateral then becomes bilateral), cranial nerve palsies (CN III, IV, V1, V2, VI), high fever with toxic appearance, altered mental status, meningeal signs

The critical distinction on exam vignettes is between Stage I (preseptal) and Stage II (postseptal/orbital). A preseptal process is managed with oral or IV antibiotics alone, while anything postseptal demands imaging, IV antibiotics, and possible surgical intervention. The exam will test whether you can identify the key discriminators: proptosis, painful or restricted extraocular movements, and decreased visual acuity all point to postseptal disease.

Feature	Preseptal Cellulitis	Orbital Cellulitis
Eyelid edema	Present	Present
Proptosis	Absent	Present
Extraocular motility	Full and painless	Restricted and/or painful
Visual acuity	Normal	May be decreased
Pupillary reflex	Normal	May show RAPD
Fever	Low-grade or absent	High-grade, toxic-appearing

3. Diagnostic Workup

Test	Role	Key Findings
Clinical examination	Initial assessment	Medial canthal edema, periorbital erythema, extraocular motility testing, visual acuity
CT sinuses and orbits with IV contrast	Best initial imaging for suspected orbital complication	Opacification of ethmoid air cells, subperiosteal abscess (rim-enhancing collection along the lamina papyracea), orbital fat stranding, proptosis
MRI brain and orbits with gadolinium	Most accurate for intracranial complications	Superior soft tissue resolution for cavernous sinus thrombosis, intracranial abscess, meningeal enhancement
MR venography	Confirmatory for cavernous sinus thrombosis	Filling defect or absent flow within the cavernous sinus
CBC, CRP, ESR, blood cultures	Systemic inflammatory assessment	Leukocytosis with left shift, elevated inflammatory markers; blood cultures positive in complicated cases
Nasal endoscopy with culture	Directed microbiologic diagnosis	Purulent drainage from the middle meatus; culture guides targeted antibiotic therapy

When to image and when not to image is a high-yield testing point. In a child with uncomplicated acute sinusitis (purulent rhinorrhea for over 10 days, or biphasic worsening, without any orbital signs), the diagnosis is clinical and imaging is not indicated. Imaging is unnecessary for routine sinusitis and is considered inappropriate in that context.

However, the moment a vignette introduces periorbital swelling, proptosis, eye pain with movement, or decreased vision in the setting of sinusitis, a CT of the sinuses and orbits with IV contrast becomes the best initial imaging study. Contrast is essential because it allows you to differentiate inflammatory edema from a drainable abscess (which will show rim enhancement).

On CT, look for: complete opacification of the ethmoid air cells, an enhancing fluid collection along the medial orbital wall (subperiosteal abscess), lateral displacement of the medial rectus, and proptosis of the globe.

If there is concern for intracranial extension (altered mental status, seizures, meningeal signs, bilateral orbital findings suggesting cavernous sinus thrombosis), MRI with gadolinium is the most accurate study. MRI provides superior soft tissue contrast for detecting dural enhancement, intracranial abscess, and venous sinus thrombosis.

4. Management and Treatment

Clinical Scenario	Treatment	Details
Uncomplicated acute ethmoiditis	Amoxicillin-clavulanate	45 mg/kg/day (amoxicillin component) divided BID for 10-14 days; high-dose (90 mg/kg/day) if risk factors for resistant organisms
Penicillin allergy	Doxycycline (adults) or clindamycin + cefixime (children)	Alternative regimens based on allergy severity
Preseptal cellulitis (Stage I)	IV ampicillin-sulbactam OR IV clindamycin	200-300 mg/kg/day (ampicillin-sulbactam) divided q6h; transition to oral when improving clinically
Orbital cellulitis / Subperiosteal abscess (Stage II-III)	IV vancomycin + ceftriaxone OR IV ampicillin-sulbactam + metronidazole	Broad-spectrum coverage including MRSA and anaerobes; urgent ophthalmology and ENT consultation
Failed medical therapy / Large abscess / Vision loss	Surgical drainage (endoscopic or external) + IV antibiotics	Indications: abscess > 1 cm, no improvement in 24-48 hours on IV antibiotics, decreased visual acuity, complete ophthalmoplegia
Cavernous sinus thrombosis (Stage V)	IV antibiotics + anticoagulation (heparin, controversial) + neurosurgical consultation	High mortality; consider anticoagulation to prevent thrombus propagation

For uncomplicated acute ethmoiditis without orbital signs, the first-line treatment is high-dose amoxicillin-clavulanate (90 mg/kg/day of the amoxicillin component, divided into two doses, for 10-14 days). This provides coverage against the most common pathogens including beta-lactamase-producing H. influenzae and M. catarrhalis. Adjunctive measures include nasal saline irrigation and intranasal corticosteroids (e.g., mometasone or fluticasone) to reduce mucosal edema and promote drainage.

If the patient fails to improve after 72 hours of first-line therapy, consider resistant organisms and broaden coverage. Options include respiratory fluoroquinolones in adults (levofloxacin 500 mg daily or moxifloxacin 400 mg daily) or high-dose amoxicillin-clavulanate with the addition of clindamycin.

When a vignette presents a child with ethmoiditis and new-onset periorbital swelling without proptosis or motility restriction, this is Stage I (preseptal cellulitis). The next best step is to admit for IV antibiotics (ampicillin-sulbactam at 200-300 mg/kg/day divided every 6 hours). Obtain a CT with contrast if there is any suspicion the process may extend beyond the septum.

If imaging reveals a subperiosteal abscess, the decision between continued medical management and surgical drainage depends on the abscess size, the patient's clinical trajectory, and the presence of visual compromise. Abscesses smaller than 1 cm in a child who is clinically stable may be managed with IV antibiotics and close serial examinations (visual acuity checks and extraocular motility assessments every 4-6 hours). If there is no improvement within 24-48 hours, or if there is any deterioration in vision, surgical drainage (typically endoscopic ethmoidectomy with abscess drainage) is indicated.

For orbital abscess or cavernous sinus thrombosis, the approach is always surgical drainage combined with prolonged IV antibiotics (typically 3-4 weeks total). Anticoagulation for cavernous sinus thrombosis remains debated, but most current guidelines favor its use to prevent thrombus propagation.

Contraindications and special considerations: Avoid fluoroquinolones in children due to the risk of cartilage toxicity (except when no safe alternative exists). In patients with penicillin allergy, stratify by severity: for mild allergy (rash), cephalosporins are safe; for severe allergy (anaphylaxis), use clindamycin plus a third-generation cephalosporin or a respiratory fluoroquinolone.

5. Differential Diagnosis and Distractors

Differential Diagnosis	Why It Is Similar	Key Discriminator
Dacryocystitis	Medial canthal swelling and erythema in a child	Swelling is localized inferior and lateral to the medial canthus (over the lacrimal sac), with tearing (epiphora) and expressible purulent material from the punctum; no sinus opacification, no nasal symptoms
Periorbital cellulitis from skin source (insect bite, trauma)	Eyelid swelling and erythema identical to preseptal cellulitis from sinusitis	History of local skin break, insect bite, or trauma without preceding URI; no purulent rhinorrhea; CT shows no sinus disease
Allergic rhinosinusitis	Nasal congestion, facial pressure, periorbital edema	Bilateral symptoms, watery (not purulent) rhinorrhea, prominent pruritus and sneezing, pale and boggy turbinates on exam, no fever
Frontal sinusitis (Pott puffy tumor)	Periorbital and forehead swelling with sinus infection	Swelling is over the forehead (not medial canthus), older adolescent or adult (frontal sinuses do not fully develop until age 12-16), CT shows frontal sinus opacification with subperiosteal abscess of the frontal bone
Orbital rhabdomyosarcoma	Proptosis and periorbital swelling in a child	Insidious onset without preceding infection, painless proptosis, no fever, no purulent rhinorrhea; imaging shows a solid orbital mass rather than sinus opacification
Neuroblastoma (orbital metastasis)	Proptosis with periorbital ecchymosis ("raccoon eyes") in a young child	Bilateral periorbital ecchymosis, abdominal mass (adrenal primary), elevated urine VMA/HVA, no sinus disease on imaging

6. Traps and High-Yield Pearls

The most common way students miss ethmoiditis questions is by failing to escalate from uncomplicated sinusitis to orbital complication. Exam vignettes are designed so that a child presents with what initially reads like a routine URI, but the stem contains subtle red flags: medial canthal swelling, pain with eye movement, or a mention that the eyelid is so swollen the child cannot open it. Students who reflexively choose "amoxicillin and follow-up in 10 days" without recognizing the orbital signs will select the wrong answer. The moment any periorbital finding appears in a sinusitis stem, the correct next step shifts to CT with contrast and IV antibiotics.

A second common trap is confusing preseptal with postseptal disease. The exam will present two nearly identical vignettes where one child has periorbital edema with full extraocular motility and normal vision (preseptal, manage medically), while the other has periorbital edema with proptosis and painful gaze restriction (postseptal, urgent imaging and likely surgical intervention). The tested competency is whether you can perform a systematic orbital examination from the vignette data: motility, vision, pupillary response, and globe position.

A third pearl is the age-anatomy relationship. If a vignette presents a toddler (age 2-5) with sinusitis complications, the involved sinus is almost certainly the ethmoid, because the maxillary and ethmoid sinuses are the only ones pneumatized at that age. The frontal sinuses begin pneumatizing around age 6-8 and are not fully developed until the mid-teenage years. A question about "Pott puffy tumor" in a 3-year-old should raise suspicion that the answer is actually ethmoiditis with orbital extension, not frontal sinusitis.

Finally, remember that the ethmoid sinus drains through the middle meatus (along with the maxillary and frontal sinuses), while the sphenoid sinus drains through the sphenoethmoidal recess. This anatomical point is tested in questions about nasal endoscopy findings and is the reason purulent drainage from the middle meatus supports a diagnosis of ethmoiditis, maxillary sinusitis, or frontal sinusitis, but not sphenoid sinusitis.

1e:["$","$L2d",null,{"article":{"id":"cba61355-c7bd-4ffe-825d-c0032cce8f34","title":"Etmoiditis","content":"$2e","category":"THT-KL","created_at":"2026-05-15T08:44:00.961422+00:00","status":"published","subcategory":null},"questionCount":0,"sections":[{"id":"section-pathophysiology","num":"01","title":"Pathophysiology"},{"id":"section-classification-and-clinical-manifestation","num":"02","title":"Classification and Clinical Manifestation"},{"id":"section-diagnostic-workup","num":"03","title":"Diagnostic Workup"},{"id":"section-management-and-treatment","num":"04","title":"Management and Treatment"},{"id":"section-differential-diagnosis-and-distractors","num":"05","title":"Differential Diagnosis and Distractors"},{"id":"section-traps-and-high-yield-pearls","num":"06","title":"Traps and High-Yield Pearls"}],"hasSummaryTable":true}]